Evidence supporting the use of: Chinese Licorice
For the body system: Cortisol

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Chinese Licorice (Glycyrrhiza uralensis) has a long history of use in Traditional Chinese Medicine (TCM), where it is often included in herbal formulas to harmonize and enhance the effects of other herbs, and to support the body's response to stress. In the context of the "Cortisol body system," which refers to the regulation of stress hormones (notably cortisol), licorice root is traditionally believed to "tonify Qi" and alleviate fatigue, which are symptoms often associated with disturbed cortisol rhythms.

From a scientific perspective, glycyrrhizin, the primary active compound in licorice, inhibits the enzyme 11β-hydroxysteroid dehydrogenase type 2. This inhibition can result in increased cortisol activity because the enzyme normally converts active cortisol to its inactive form, cortisone, in certain tissues. Some studies have confirmed that licorice can increase circulating cortisol and mimic effects similar to mineralocorticoid excess. However, this is generally considered a side effect rather than a therapeutic benefit, as it can lead to issues like hypertension and electrolyte imbalance.

Overall, while there is a traditional basis for using licorice to support stress adaptation and energy, scientific validation for its safe and effective use specifically to support healthy cortisol regulation is limited. Most clinical guidance cautions about its potential to disrupt rather than support normal cortisol physiology.

More about Chinese Licorice
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