Evidence supporting the use of: Fungus
For the body system: Cortisol

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fungi, particularly adaptogenic mushrooms like Cordyceps, Reishi (Ganoderma lucidum), and Chaga, have been researched for their potential role in modulating the body's stress response, including the hypothalamic-pituitary-adrenal (HPA) axis that governs cortisol production. Several preclinical (animal and in vitro) studies and a few small-scale human trials suggest that these mushrooms may influence cortisol levels and help the body adapt to stress. For instance, Reishi has demonstrated potential in reducing markers of stress and modulating immune and endocrine functions in animal models. Cordyceps has been shown in some studies to help maintain normal cortisol levels during physical and environmental stress. Human evidence, while promising, is limited in scale and often methodologically weak, with some trials reporting subjective improvements in stress and fatigue. Overall, the scientific basis for fungi supporting the cortisol system is moderately strong at the preclinical level, but larger, high-quality clinical studies are needed for conclusive evidence. Therefore, fungi are used for cortisol support primarily due to emerging scientific research rather than tradition, placing the evidence at a moderate level.

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