Evidence supporting the use of: Ginseng, Panax
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Panax ginseng is commonly used to support the body's stress response, and its effects on cortisol—the primary stress hormone—have been the subject of scientific investigation. Research suggests that ginsenosides, the active compounds in Panax ginseng, may modulate the hypothalamic-pituitary-adrenal (HPA) axis and influence cortisol secretion. Several animal and small human studies indicate that Panax ginseng can help normalize elevated cortisol levels in response to stress, potentially enhancing resilience and reducing fatigue. For example, a 2013 randomized controlled trial found that ginseng supplementation led to slightly lower cortisol responses after stress-inducing tasks. However, the evidence is mixed: some trials have not found significant effects, and sample sizes are generally small. Traditional use of Panax ginseng as an adaptogen supports its role in managing stress and promoting overall vitality, but direct references to cortisol regulation are a modern development grounded in pharmacological studies. Overall, there is moderate scientific support for Panax ginseng’s ability to influence the cortisol system, but more robust, large-scale clinical trials are needed to confirm efficacy and clarify the mechanisms involved.

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