Evidence supporting the use of: Ginseng, Siberian
For the body system: Cortisol

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Siberian ginseng (Eleutherococcus senticosus), also known as eleuthero, has a long history of use in traditional Chinese and Russian herbal medicine as an adaptogen—a substance believed to help the body resist physical, environmental, and emotional stressors. The rationale for using Siberian ginseng to support the "cortisol body system" stems from its adaptogenic reputation, as adaptogens are thought to modulate the body's stress response, which involves the hypothalamic-pituitary-adrenal (HPA) axis and the release of cortisol.

Historically, Siberian ginseng has been used to increase endurance, reduce fatigue, and improve resilience to stress, but these uses are supported mainly by tradition and anecdotal reports. Scientific studies on Siberian ginseng and its effects on cortisol levels or direct HPA axis modulation are limited and generally of low quality. Some small clinical trials have suggested possible anti-fatigue and modest stress-mitigating effects, but consistent, well-controlled evidence for direct cortisol regulation is lacking. Reviews generally conclude that while there is some promise, the evidence base is insufficient to confirm efficacy for cortisol modulation.

In summary, the use of Siberian ginseng to support the cortisol system is primarily justified by traditional rather than robust scientific evidence, with a low (2/5) rating for strength of evidence.

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