Evidence supporting the use of: Ginsenoside
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ginsenosides are the primary active components of ginseng (Panax species), which has a long history in traditional medicine for its adaptogenic properties, including support for stress resilience and energy. Modern scientific studies have investigated ginsenosides for their effects on the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production—the primary stress hormone in the human body. Preclinical research (in vitro and animal studies) suggests that certain ginsenosides, such as Rg1 and Rb1, may modulate the HPA axis response to stress, potentially normalizing or attenuating excessive cortisol release. Some small human trials and clinical studies have observed that ginseng supplementation can reduce perceived stress and fatigue, and may influence biomarkers associated with the stress response, including cortisol levels. However, results are mixed, and the methodological quality of many studies is variable. There is insufficient large-scale, high-quality clinical evidence to conclusively confirm that ginsenosides directly and significantly support cortisol regulation in humans. Therefore, while the use of ginsenosides to support the cortisol system is scientifically plausible and supported by some preliminary evidence, more rigorous research is needed to establish efficacy and mechanism of action.

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Products containing Ginsenoside

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