Evidence supporting the use of: Ginsenosides
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginsenosides are the primary active compounds found in ginseng (Panax ginseng), a traditional herbal remedy used in Asian medicine. There is some scientific evidence suggesting that ginsenosides may modulate the hypothalamic-pituitary-adrenal (HPA) axis, which governs cortisol production and stress responses. Preclinical studies, including in vitro and animal models, have shown that certain ginsenosides (such as Rg1 and Rb1) can influence the secretion of adrenocorticotropic hormone (ACTH) and corticosterone, indirectly affecting cortisol levels. Additionally, some human clinical trials indicate that ginseng supplementation may help mitigate stress-induced increases in cortisol, though sample sizes are often small and methodologies vary.

Despite these findings, the clinical evidence is limited and somewhat inconsistent. While ginsenosides are widely promoted in supplements for "adrenal support" or "stress balance," robust, large-scale, placebo-controlled human trials are lacking. Most available studies do not isolate ginsenosides from other ginseng components, making it difficult to attribute effects specifically to these compounds. Overall, the use of ginsenosides to support healthy cortisol function is partially justified by scientific findings, but the evidence is not strong or definitive.

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Products containing Ginsenosides

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