Evidence supporting the use of: Ginsenosides (unspecified)
For the body system: Cortisol

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ginsenosides are the primary active compounds found in Panax ginseng and related species, widely used in traditional Chinese medicine (TCM) and other Asian systems for their reputed adaptogenic properties. Traditionally, ginseng has been used to promote vitality, increase resistance to stress, and restore balance to bodily systems, which includes managing the body's response to stressors—often understood today in terms of the hypothalamic-pituitary-adrenal (HPA) axis and cortisol regulation. Ginseng preparations have been employed historically to combat fatigue, improve energy, and support overall well-being, effects that are sometimes attributed to the modulation of stress hormones like cortisol. Modern research offers some preliminary evidence that ginsenosides may influence the HPA axis and cortisol levels, though data are limited. Animal and in vitro studies suggest ginsenosides can modulate stress responses, potentially reducing excessive cortisol secretion or enhancing stress adaptation. However, robust clinical data in humans are sparse, and studies often suffer from small sample sizes or methodological limitations. Thus, while there is a clear traditional basis for using ginsenosides to support the body's stress response—interpreted in contemporary settings as “cortisol support”—scientific validation remains preliminary. Most current uses for cortisol modulation are founded more on traditional practices than on strong clinical evidence.

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