Evidence supporting the use of: Licorice
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Licorice (Glycyrrhiza glabra) has a long history of use in traditional medicine systems, particularly in Traditional Chinese Medicine and Ayurveda, where it is often used as an adaptogen and to support adrenal health. Scientifically, licorice is notable for its active compound, glycyrrhizin, which inhibits the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). This enzyme normally converts active cortisol to inactive cortisone in the kidneys. By inhibiting 11β-HSD2, glycyrrhizin can increase systemic levels of cortisol. This mechanism has been demonstrated in multiple human and animal studies, leading to effects such as apparent mineralocorticoid excess when consumed in high amounts, with symptoms like hypertension and hypokalemia.

Some research suggests that by slowing the breakdown of cortisol, licorice may support adrenal function in cases of adrenal fatigue or insufficient cortisol production, although "adrenal fatigue" itself is not broadly recognized in conventional medicine. Licorice is sometimes used as an adjunct in the treatment of Addison’s disease (adrenal insufficiency), but only under medical supervision due to its potential side effects. Overall, while there is a plausible and documented mechanism for licorice's effects on cortisol metabolism, clinical evidence for its safe and effective use specifically to "support the cortisol body system" in healthy individuals is limited, and use should be approached with caution.

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