Evidence supporting the use of: Licorice (unspecified)
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Licorice (Glycyrrhiza glabra) has been traditionally used in herbal medicine for a variety of purposes, including as an adaptogen to support stress response. Scientifically, licorice contains glycyrrhizin, which inhibits the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). This enzyme converts active cortisol to its inactive form, cortisone. By inhibiting this conversion, licorice can increase the availability and action of cortisol in the body. Several studies have confirmed this biochemical effect, and licorice is used in some clinical settings (for example, in cases of Addison’s disease or chronic fatigue) to help prolong the action of endogenous or exogenous corticosteroids.

However, the evidence for licorice’s efficacy in supporting the "cortisol body system"—meaning, to directly improve stress adaptation or adrenal function in otherwise healthy individuals—is limited to moderate. Most human data focus on biochemical changes and the potential risks of excessive use (such as hypertension, edema, and hypokalemia) rather than robust clinical outcomes. Traditional use and some mechanistic studies do provide rationale for its use, but well-designed clinical trials are lacking. Therefore, while there is a clear biological mechanism and moderate scientific support for licorice’s effect on cortisol metabolism, claims about its general benefits for stress or adrenal health should be viewed cautiously.

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