Evidence supporting the use of: Panax Ginseng
For the body system: Cortisol

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Panax Ginseng has a long history of use in traditional medicine, particularly in East Asia, as an adaptogen—an agent thought to help the body resist stressors. Modern scientific research has provided some evidence supporting its role in modulating the body’s stress response, including effects on cortisol, a key hormone released during stress.

Several studies in humans and animals suggest that Panax Ginseng may help regulate the hypothalamic-pituitary-adrenal (HPA) axis, which controls cortisol production. For example, some randomized controlled trials have shown that ginseng supplementation can attenuate cortisol elevations induced by physical or psychological stress, although the results are not universally consistent and often depend on the dosage, duration, and subject population. The proposed mechanisms include ginsenosides (active compounds in Panax Ginseng) influencing corticosteroid receptors and modulating inflammatory pathways that interact with the HPA axis.

While systematic reviews and meta-analyses indicate that there is preliminary evidence for ginseng’s adaptogenic properties, most experts agree that more large-scale, high-quality trials are needed to confirm its effects specifically on cortisol regulation. Nevertheless, based on current evidence, Panax Ginseng is used to support the cortisol body system with moderate scientific backing.

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