Rhodiola (typically Rhodiola rosea) is an adaptogenic herb traditionally used in Russia and Scandinavia for enhancing physical and mental endurance. In relation to cortisol, the primary stress hormone, there is moderate scientific evidence that Rhodiola can help modulate the body’s stress response. Several randomized controlled trials and animal studies have shown that Rhodiola supplementation may decrease stress-induced fatigue and normalize cortisol levels, especially during acute stress situations. The proposed mechanism involves the modulation of the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production and release.

For example, a 2009 study in Phytomedicine found that Rhodiola supplementation reduced cortisol response and improved symptoms of burnout compared to placebo. Other clinical studies have observed improvements in mental performance and perceived stress, with accompanying stabilization of cortisol levels. However, the number of high-quality, large-scale studies remains limited, and results are not entirely consistent across all trials.

Overall, the use of Rhodiola to support the cortisol body system is supported by moderate scientific evidence, particularly for stress-related fatigue and mild HPA axis modulation. More research is needed to establish optimal dosing, long-term effects, and efficacy in broader populations.