Evidence supporting the use of: Rosarin
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rosarin is a phenylpropanoid glycoside compound found in Rhodiola rosea (commonly known as golden root or Arctic root), a plant traditionally used in Eurasian folk medicine as an adaptogen to combat fatigue and enhance resilience to stress. Scientific research in recent decades has focused on Rhodiola extracts and their ability to modulate the body's stress response, particularly through effects on the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production. Several preclinical and clinical studies suggest that standardized extracts of Rhodiola rosea containing rosarin (along with related compounds such as salidroside and rosavin) may help normalize cortisol levels and reduce stress-induced elevations in this hormone. For example, a 2009 randomized controlled trial (Olsson et al., Planta Med) found that Rhodiola supplementation reduced stress symptoms and improved mental performance, with some evidence of stabilization of cortisol secretion. However, while these studies generally use whole Rhodiola extracts, rosarin is often cited as one of the marker compounds responsible for adaptogenic effects. Direct studies on isolated rosarin and its specific effects on cortisol regulation are limited, so the current scientific evidence primarily supports the use of the whole plant or extract, not rosarin alone. In summary, while there is scientific evidence that Rhodiola extracts containing rosarin support healthy cortisol responses, the evidence for rosarin specifically is less robust, meriting a moderate rating.

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