Evidence supporting the use of: Rosavins
For the body system: Cortisol

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rosavins are a group of compounds found in Rhodiola rosea, a plant traditionally used in Eastern Europe and Asia as an adaptogen—substances believed to help the body resist physical, chemical, and biological stressors. Scientific interest in rosavins primarily relates to their potential effects on the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production. Several animal and human studies suggest that standardized extracts of Rhodiola rosea containing rosavins may help modulate cortisol levels in response to stress. For instance, a 2009 randomized, double-blind, placebo-controlled study (Shevtsov et al., 2003; Olsson et al., 2009) showed that supplementation with Rhodiola rosea extract resulted in a blunted cortisol response to stress in healthy volunteers. Additional research has indicated improvements in symptoms related to chronic fatigue and stress-induced burnout, which are often associated with dysregulated cortisol secretion. However, while these findings are promising, the quality and scale of the studies remain limited, sample sizes are often small, and most research is on whole-root extracts rather than isolated rosavins. Thus, while there is moderate scientific support for the use of rosavins to support the cortisol body system, more robust clinical trials are needed to substantiate efficacy and clarify mechanisms of action.

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