Evidence supporting the use of: Rosavins (mixed)
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rosavins are a group of compounds found primarily in the root of Rhodiola rosea, a plant traditionally used in Russian and Scandinavian medicine as an adaptogen for combating stress and fatigue. The "cortisol body system" refers to the regulation of cortisol, the primary stress hormone produced by the adrenal glands. Several clinical and preclinical studies suggest that Rhodiola rosea extracts standardized to rosavins can help modulate the body's stress response, possibly by influencing the hypothalamic-pituitary-adrenal (HPA) axis and cortisol secretion.

Randomized controlled trials have shown that Rhodiola rosea supplementation may reduce perceived stress and fatigue, with some studies noting a blunted rise in cortisol in response to stress. For example, a 2009 clinical trial (Olsson et al., Phytomedicine) found that Rhodiola supplementation led to a reduction in salivary cortisol levels and improved stress symptoms. Mechanistically, animal studies suggest that rosavins may modulate components of the HPA axis, reducing excessive cortisol release during stress.

However, while several lines of evidence point to a beneficial effect of rosavins on the stress response and cortisol modulation, the quality and size of clinical trials are moderate, and more research is needed for definitive conclusions. Therefore, the evidence is rated as moderate (3/5): scientific support exists but is not definitive or universally accepted by the medical community.

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