Rosevin is a branded extract of Rhodiola rosea, a well-known adaptogenic herb. Scientific studies have shown that Rhodiola rosea can help modulate the body's stress response, including effects on the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production and release. Several randomized controlled trials and systematic reviews have indicated that Rhodiola rosea supplementation may reduce fatigue, improve mental performance, and help normalize stress-induced elevations in cortisol levels. For example, a 2012 systematic review (Ishaque et al., 2012) concluded that Rhodiola has a favorable effect on physical and mental fatigue under stress. Mechanistically, Rhodiola is thought to exert its effects by influencing key mediators in the HPA axis, thereby supporting balanced cortisol secretion during periods of psychological or physical stress. While the majority of human studies use standardized Rhodiola extracts (often containing rosavins and salidroside, which are also found in Rosevin), there is a strong body of evidence supporting the adaptogenic properties of this botanical. However, heterogeneity in study design and extract standardization means that more research is needed for definitive clinical recommendations. Overall, Rosevin is used to support the body's cortisol balance primarily on the basis of clinical and preclinical evidence for Rhodiola rosea.