Evidence supporting the use of: Salidrosides
For the body system: Cortisol

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Salidroside, a primary bioactive compound of Rhodiola rosea, is often promoted for its adaptogenic properties, particularly in modulating the body's stress response and supporting healthy cortisol levels. Scientific research, primarily in vitro and animal studies, has demonstrated that salidroside can influence the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production. Several studies report that salidroside may reduce stress-induced elevations in cortisol, potentially by modulating gene expression related to stress and promoting resilience to physical and psychological stressors.

Clinical trials in humans are limited but suggest a potential benefit: for example, small randomized controlled trials with Rhodiola rosea extracts (which contain salidroside along with other compounds) have shown reduction of self-reported stress and fatigue, and some measured decreases in cortisol levels. However, the direct effect of isolated salidroside on cortisol regulation in humans remains less well established.

Overall, while there is a traditional basis for using Rhodiola rosea as an adaptogen, the scientific evidence specifically supporting salidroside for cortisol modulation is moderate and based mostly on preclinical data and studies of whole plant extracts. More rigorous, large-scale human clinical trials are needed to confirm salidroside’s specific effects on the cortisol system.

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