Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Whole adrenal glandular supplements are primarily justified by tradition rather than robust scientific validation. These supplements are derived from animal adrenal glands (typically bovine or porcine) and have been used in naturopathic and alternative medicine for decades to support "adrenal health" and, by extension, the body's cortisol system. The rationale is that consuming glandular extracts may provide nutrients or bioactive compounds that nourish or restore adrenal function, especially in cases of so-called "adrenal fatigue"—a condition not widely recognized by conventional medicine.

However, scientific evidence specifically supporting the efficacy of whole adrenal glandulars for modulating cortisol levels or supporting adrenal function is extremely limited. Most clinical studies on adrenal support focus on pharmaceutical interventions or lifestyle changes, not glandular extracts. Furthermore, the digestive process is likely to break down the proteins and hormones present in glandular supplements, making it unlikely that intact adrenal hormones or factors reach the bloodstream in meaningful amounts.

Despite this, their use persists in traditional and holistic circles, often based on historical precedent and anecdotal reports rather than rigorous clinical trials. Regulatory agencies such as the FDA do not recognize these supplements as effective for treating adrenal insufficiency or related disorders. In summary, the use of whole adrenal glandulars to support the cortisol system remains rooted in tradition with little scientific backing.

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