Evidence supporting the use of: Cineole
For the health condition: Cough (damp)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cineole, also known as eucalyptol, is a monoterpene found in eucalyptus oil and other plant essential oils. Its use for cough, particularly “damp” cough characterized by excessive mucus production, is supported by scientific evidence. Clinical studies and systematic reviews have demonstrated that cineole possesses expectorant, mucolytic, anti-inflammatory, and bronchodilatory effects that can alleviate symptoms associated with respiratory tract diseases, such as bronchitis and sinusitis. In randomized controlled trials, cineole has been shown to improve mucociliary clearance, reduce sputum viscosity, and ease coughing in patients with acute and chronic bronchitis. For example, a 2012 double-blind, placebo-controlled trial in patients with acute bronchitis found that cineole significantly reduced cough frequency and improved breathing compared to placebo. Its anti-inflammatory properties have also been documented in vitro and in animal models, with evidence of reduced cytokine production and inhibition of bronchial hyperreactivity. The European Medicines Agency (EMA) acknowledges cineole as a traditional and well-established herbal medicinal product for the relief of cough and mild upper respiratory tract conditions. However, while the evidence base is moderately strong, most studies are of short duration and focus on mild-to-moderate cases. Thus, cineole is scientifically validated for use in relieving coughs with excessive mucus, with a moderate level of clinical evidence.

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