Evidence supporting the use of: Boneset
For the health condition: Cough (dry)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Boneset (Eupatorium perfoliatum) has a long history of traditional use in North American herbal medicine, especially among Native American tribes and early European settlers. It was commonly used to treat fevers, influenza, and respiratory ailments, including coughs—particularly those associated with colds and influenza. The plant was often prepared as a tea or infusion and was reputed to help break fevers and relieve symptoms such as muscle aches and dry coughs. The traditional rationale is that boneset acts as a diaphoretic (promoting sweating) and expectorant, thus helping to loosen and expel mucus and relieve dryness in the respiratory tract.

However, scientific validation for boneset’s effectiveness for dry cough is limited. While some laboratory studies have explored its anti-inflammatory and immunomodulatory properties, clinical trials in humans are lacking. The available evidence comes primarily from historical accounts and herbalist writings rather than modern, controlled scientific studies. As such, its use for dry cough remains rooted in tradition rather than robust clinical evidence. Caution should also be exercised due to potential toxicity with improper use, as some constituents of boneset may be hepatotoxic. Overall, boneset’s use for dry cough is primarily justified by traditional use rather than scientific validation.

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