Evidence supporting the use of: Flavonoid glycosides
For the health condition: Cough (dry)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Flavonoid glycosides, a group of plant-derived compounds known for their anti-inflammatory and antioxidant properties, have a long history of use in traditional medicine, especially in herbal remedies for respiratory ailments such as dry cough. Plants rich in flavonoid glycosides—such as elderflower (Sambucus nigra), licorice (Glycyrrhiza glabra), and mullein (Verbascum thapsus)—have been included in traditional cough syrups and teas for centuries. The rationale behind their use is primarily based on their reputed ability to soothe mucous membranes and reduce irritation in the throat, as well as their mild expectorant effects.

However, scientific validation specifically for flavonoid glycosides in the treatment of dry cough is limited. Most evidence comes from in vitro or animal studies demonstrating general anti-inflammatory and antioxidant effects, rather than direct clinical trials on dry cough relief in humans. Some studies suggest flavonoids may modulate immune response and inhibit histamine release, potentially reducing cough reflex sensitivity. Nevertheless, these findings are preliminary and do not constitute robust clinical proof. Thus, the use of flavonoid glycosides for dry cough remains grounded primarily in traditional practice, with a modest (level 2/5) evidence rating due to lack of high-quality clinical research.

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