Evidence supporting the use of: Glycyrrhizic acid
For the health condition: Cough (dry)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhizic acid, a primary active compound found in licorice root (Glycyrrhiza glabra), has been traditionally used in many cultures, especially in Chinese and other Asian herbal medicine systems, to soothe the throat and alleviate dry cough. Historical texts and traditional formulas frequently include licorice root as a demulcent and expectorant, often prescribed for conditions involving irritation of the respiratory tract, including dry cough. The soothing properties are attributed to glycyrrhizic acid’s ability to increase mucus secretion, which can help coat and protect the mucous membranes of the throat, reducing the urge to cough.

While there are some preclinical and small-scale clinical studies suggesting anti-inflammatory and soothing effects of glycyrrhizic acid and licorice extracts on the respiratory tract, robust scientific evidence specifically supporting its efficacy for dry cough in humans is limited. Most of the evidence supporting its use comes from traditional medicine practices and anecdotal reports rather than large, controlled clinical trials. Thus, while its use is well-established in traditional medicine, modern clinical validation for this specific indication remains modest.

In summary, glycyrrhizic acid’s use for dry cough is primarily based on traditional use, with some supporting mechanistic data but only limited clinical validation.

More about glycyrrhizic acid
More about Cough (dry)

Products containing glycyrrhizic acid

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