Evidence supporting the use of: Glycyrrhizinic acid
For the health condition: Cough (dry)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhizinic acid, a primary component of licorice root (Glycyrrhiza glabra), has been traditionally used in various systems of medicine, including Traditional Chinese Medicine (TCM) and Ayurveda, to soothe respiratory ailments such as dry cough. Historical records and pharmacopeias describe licorice as a demulcent, which means it can soothe irritated mucous membranes in the respiratory tract, thereby reducing the urge to cough. In TCM, licorice is often included in herbal formulas to "harmonize" the effects of other herbs and to address coughs and sore throats.

On the scientific side, preclinical studies have demonstrated that glycyrrhizinic acid and its aglycone, glycyrrhetinic acid, possess anti-inflammatory and soothing effects on mucosal tissues, which could theoretically benefit dry cough. Some in vitro and animal studies suggest expectorant and antitussive properties, but robust clinical trials in humans are lacking. While there is some mechanistic plausibility, the direct evidence supporting its effectiveness for dry cough is weak and mainly extrapolated from traditional use and animal studies rather than well-conducted human trials.

In summary, the use of glycyrrhizinic acid for dry cough is primarily supported by a long tradition of use in herbal medicine, with limited scientific validation. Caution is advised due to potential side effects of glycyrrhizinic acid, such as hypertension and hypokalemia, especially with prolonged use.

More about Glycyrrhizinic acid
More about Cough (dry)

Products containing Glycyrrhizinic acid

We currently have no products on Vitabase that contain this ingredient.