Evidence supporting the use of: Glycyrrhizinic acid
For the health condition: Cough (general)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Glycyrrhizinic acid, a major bioactive component of licorice root (Glycyrrhiza glabra), has been traditionally used for centuries in various cultures to alleviate cough and soothe irritated throats. In Traditional Chinese Medicine (TCM), licorice is a key ingredient in many herbal formulas for respiratory conditions, including cough, bronchitis, and sore throat. Similarly, traditional European and Middle Eastern herbal medicine systems have long employed licorice preparations for their demulcent (soothing) and expectorant properties.

Scientific studies suggest that glycyrrhizinic acid exhibits anti-inflammatory, antiviral, and immunomodulatory effects, which could theoretically be beneficial in treating coughs, especially those caused by viral or inflammatory processes. Some in vitro and in vivo studies have shown that glycyrrhizin can suppress the replication of certain viruses that cause respiratory illness and reduce airway inflammation. Moreover, it has mild expectorant action, which can help loosen mucus in the airways. However, human clinical trials specifically evaluating glycyrrhizinic acid for cough are limited, and most evidence comes from broader studies on licorice root or traditional formulations containing it.

In summary, the use of glycyrrhizinic acid for cough is well-supported by historical and traditional use, with moderate scientific plausibility based on its known pharmacological activities. Nevertheless, robust clinical data specifically confirming its efficacy for cough in humans are lacking.

More about Glycyrrhizinic acid
More about Cough (general)

Other ingredients used for Cough (general)

allspice
aloe vera
alpha-pinene
apple
waterhyssop
bamboo
basil
benegut perilla (proprietary)
beta-pinene
black cumin
black currant
black pepper
radish
Indian frankincense
carrot
cassia bark
cat's claw
chen pi
Chinese salvia root
cinnamon
clove
cowage seed
turmeric
elderberry
fennel
garlic bulb
ginger
glehnia root
grape
greek mountain tea
onion
green tea
heartwood
Indian tinospora
jujube
lemon
licorice root
lovage
marshmallow
nettle
ophiopogon root
orange
oregano
parsley
pear
perilla
phellodendron amurense
platycodon root
plum fruit
polygala root
pomegranate
pumpkin
raspberry
spearmint leaf
sphaeranthus indicus
thyme
vitamin C
zhejiang fritillary
zinc
sarsaparilla
boneset
mullein
tangerine
hyssop
atractylodes
lobelia
capsicum
Indian bael
neem tree
malabar nut
alpinia galangal
ferula assafoetida
hedychium spicatum
inula racemosa
anise
pistacia integerrima gall
punarnava
fumaria parviflora
prickly ash
fritillaria
lemongrass
yerba santa
elecampane
coltsfoot
root tuber
silk tree
juniper berries
amber
dodder
sweet flag
hyacinth bean
eucalyptus
menthol oil
peach
abies spectabilis
horehound
soursop
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Aralia
Apple Cider Vinegar
Agastache
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Alpha-terpineol
Ambergris
Ardisia
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acacia
Agave
Allicin
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Abrus
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Albizia
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Allium tuberosum
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Asarum sieboldii
Alantolactone
Atractylone
Black Seed
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Bryonia
Blepharis
Bayleaf
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Bougainvillea
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berry
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black salt
Bee products
Borassus Palm
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Borassus aethiopum
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banana
Bassia scoparia
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Cubeb
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Chaenomeles lagenaria
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Cyanthillium cinereum
Cinnamaldehyde
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cola nut
Celosia
Clerodendrum indicum
Culvers Root
Currant
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Dragonhead
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Desmodium
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Products containing Glycyrrhizinic acid

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