Evidence supporting the use of: Belladonna
For the health condition: Cough (spastic)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Belladonna (Atropa belladonna), also known as deadly nightshade, has a long history of use in traditional medicine for a variety of ailments, including respiratory conditions such as spastic cough (often described historically as "nervous" or "irritable" coughs). The primary active compounds in belladonna are tropane alkaloids, notably atropine and scopolamine, which have anticholinergic (muscarinic receptor-blocking) effects. These compounds can reduce secretions and exert a bronchodilatory and antispasmodic effect, which theoretically could help to relieve spastic cough by relaxing the smooth muscle of the airways and reducing involuntary contractions.

Historically, belladonna preparations were included in cough syrups and tinctures in Europe and North America during the 19th and early 20th centuries. However, clinical studies specifically evaluating belladonna for cough are very limited or absent, and modern medicine does not recommend its use due to safety concerns, including toxicity and a narrow therapeutic window. The use of belladonna for spastic cough persists in some homeopathic and herbal traditions, but this is not supported by robust scientific data.

In summary, belladonna's use for spastic cough is primarily justified by tradition and historical practice, not by strong scientific evidence. Its use today is rare due to safety issues, and better-studied, safer alternatives are available.

More about Belladonna
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