Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Perilla (Perilla frutescens) has been widely used in traditional East Asian medicine, particularly within Traditional Chinese Medicine (TCM) and Kampo (Japanese herbal medicine). In these traditions, perilla leaves and seeds are often used for respiratory conditions, including coughs (especially those characterized as spasmodic or associated with bronchospasm), asthma, and phlegm. The traditional rationale is based on perilla's reputed abilities to "dispel wind-cold," "alleviate cough," and "calm wheezing." In TCM, it is typically included in herbal formulas rather than used alone, and is thought to support lung function and modulate immune responses. Modern scientific evidence supporting perilla's efficacy for spastic cough is limited. Preclinical studies have demonstrated that perilla extracts contain rosmarinic acid, luteolin, and other flavonoids with anti-inflammatory, antiallergic, and bronchodilatory properties. Some animal studies indicate perilla oil and extracts may help reduce airway inflammation and hyperreactivity. However, high-quality clinical trials specifically evaluating perilla (or proprietary blends like "benegut perilla") for spastic cough in humans are lacking. Therefore, while perilla is traditionally used for cough and related respiratory symptoms, robust scientific validation is absent, and the evidence for efficacy remains modest, meriting a rating of 2.

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