Evidence supporting the use of: Flavoglycosides
For the health condition: Cough (spastic)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Flavoglycosides are naturally occurring compounds found in various medicinal plants, commonly known for their role as plant secondary metabolites. Their use in supporting or treating spastic cough (a type of dry, irritating cough often associated with bronchial irritation) is primarily rooted in traditional herbal medicine practices rather than robust scientific evidence. Historically, plants rich in flavoglycosides, such as elderflower (Sambucus nigra), linden (Tilia species), and others, have been utilized in traditional European and Asian medicine for their purported antitussive and soothing effects on the respiratory tract. These effects are attributed to the anti-inflammatory, antioxidant, and mild spasmolytic properties of certain flavoglycosides. However, while in vitro and animal studies suggest that some flavoglycosides may exert anti-inflammatory or antispasmodic actions, clinical studies specifically evaluating their efficacy for spastic cough in humans are lacking or limited in quality and scope. Most modern pharmacopeias and systematic reviews conclude that evidence supporting the use of flavoglycosides for this indication is weak and based largely on traditional use rather than rigorous clinical trials. Therefore, their use for spastic cough remains primarily justified by historical and traditional practices, with only limited preclinical scientific support.

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