Evidence supporting the use of: Glycyrrhizic acid
For the health condition: Cough (spastic)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhizic acid, a major active component of licorice root (Glycyrrhiza glabra), has a long history of use in traditional medicine systems, particularly in Traditional Chinese Medicine (TCM) and Ayurveda, for the treatment of various respiratory ailments, including coughs. In TCM, licorice is often included in herbal formulas intended to soothe the throat, reduce phlegm, and alleviate spasmodic (spastic) coughs due to its demulcent and anti-inflammatory properties. Historical texts and pharmacopoeias document such uses, attributing them to the soothing effects of glycyrrhizic acid and related compounds on mucous membranes.

Scientifically, there is some evidence from preclinical studies suggesting that glycyrrhizic acid possesses anti-inflammatory, antitussive (cough-suppressing), and expectorant activities. However, robust clinical trials evaluating its efficacy specifically for spastic cough in humans are limited. Most support comes from animal studies or extrapolation from its general anti-inflammatory effects. While these findings provide a partial pharmacological rationale, they do not reach the standard of strong clinical validation.

In summary, the use of glycyrrhizic acid for spastic cough is primarily rooted in traditional medical practices, with limited but suggestive scientific support. The evidence base is not strong, and more rigorous human studies are needed to confirm its efficacy and safety for this indication.

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