Evidence supporting the use of: Phenolics (various)
For the health condition: Cough (spastic)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Phenolics, a broad class of plant-derived compounds that includes substances like thymol, eugenol, and various flavonoids, have a long history of use in traditional medicine for treating coughs, including spastic (dry, irritating) coughs. Various herbal remedies and expectorants employed in folk medicine—such as thyme, clove, and certain polyherbal cough syrups—derive part of their activity from phenolic constituents. These compounds may exhibit mild antitussive, anti-inflammatory, or soothing effects on the respiratory tract, which could contribute to symptomatic relief. However, the scientific evidence directly supporting the efficacy of phenolics for spastic cough is limited and largely based on in vitro studies or animal models demonstrating anti-inflammatory or antimicrobial properties. Clinical trials in humans are sparse, and most data come from traditional usage rather than rigorous scientific validation. Therefore, while there is a historical basis for their inclusion in cough remedies, and some plausible mechanistic support, robust clinical evidence is lacking, justifying a modest evidence rating.

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