Evidence supporting the use of: Vasicinone
For the health condition: Cough (spastic)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vasicinone is an alkaloid derived from the plant Adhatoda vasica (also known as Malabar nut), which has a long history of use in traditional Ayurvedic medicine primarily for treating respiratory ailments, including cough and asthma. Scientific investigations have revealed that vasicinone, along with its related alkaloid vasicine, exhibits bronchodilatory, expectorant, and mild antitussive (cough-suppressing) properties. Several preclinical studies (e.g., Gupta et al., 1978; Chopra et al., 1956) have demonstrated that vasicinone can relax bronchial smooth muscle and increase bronchial secretions, helping to clear mucus and ease coughing.

However, robust clinical data in humans are lacking. Most of the supportive evidence comes from animal models or in vitro studies showing that vasicinone can reduce bronchospasm and may have a mild cough-suppressant effect, especially in cases of spastic (irritable) cough associated with bronchial constriction. Its use in modern herbal formulations for cough is often based on this combination of traditional reputation and early pharmacological data. There are no large-scale, high-quality randomized controlled trials directly evaluating vasicinone for spastic cough in humans. Therefore, while there is a plausible scientific basis for its use, the evidence is limited and should be considered preliminary.

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