Evidence supporting the use of: Angel's Trumpet
For the health condition: Cramps and Spasms

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Angel's Trumpet (Brugmansia spp.) is primarily recognized in traditional medicine systems, particularly among indigenous cultures in South America, for its medicinal uses. Historically, the plant has been used as a sedative, antispasmodic, and analgesic, thanks to its content of tropane alkaloids such as scopolamine, hyoscyamine, and atropine. These alkaloids possess anticholinergic properties, which can theoretically reduce muscle spasms and cramps by inhibiting acetylcholine-mediated neuromuscular activity. Ethnobotanical records document the use of Angel's Trumpet preparations in folk remedies for a variety of ailments, including muscle cramps, spasms, and pain. However, these uses come with significant risks, as the therapeutic window is very narrow and the plant is highly toxic.

From a scientific perspective, while the anticholinergic effects of tropane alkaloids are well-documented and could explain the traditional use for cramps and spasms, there is a lack of controlled clinical trials or rigorous scientific studies specifically investigating Angel's Trumpet for this indication. Modern medicine employs purified tropane alkaloids (like those from Atropa belladonna) in some antispasmodic drugs, but the use of crude preparations from Angel's Trumpet is not recommended due to severe toxicity risks, including delirium, hallucinations, and potentially fatal poisoning.

In summary, the use of Angel's Trumpet for cramps and spasms is justified by traditional practices, with moderate plausibility based on its pharmacology, but lacks robust scientific validation and is considered unsafe.

More about Angel's Trumpet
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