Asafetida (Ferula assa-foetida) has a long-standing history in traditional medicine systems, particularly in Ayurveda and Unani, for the treatment of a variety of digestive complaints, including abdominal cramps and spasms. Its use as an antispasmodic is primarily based on empirical evidence and centuries of traditional practice, rather than robust scientific validation. In these traditional systems, asafetida is believed to relieve flatulence, bloating, and intestinal colic by relaxing smooth muscle in the gut. The resin is often incorporated into remedies for stomach pain and cramping associated with indigestion or menstrual discomfort.

Scientific research on asafetida's antispasmodic effects is limited, but a few preclinical studies suggest that extracts of asafetida can relax smooth muscle tissue in animal models, possibly due to its volatile oil components and compounds such as ferulic acid. However, these findings are preliminary, and there is a lack of well-conducted human trials to confirm its efficacy for cramps and spasms. Therefore, while traditional use is extensive and consistent for this purpose, the level of scientific evidence supporting its effectiveness is low, warranting a rating of 2 out of 5 for evidence.