Evidence supporting the use of: Magnesium citrate malate
For the health condition: Cramps (leg)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Magnesium citrate malate is used to support or treat leg cramps due to scientific evidence linking magnesium deficiency with muscle cramps, including those in the legs. Magnesium plays a crucial role in neuromuscular transmission and muscle contraction. Several studies have examined magnesium supplementation for muscle cramps, particularly in populations prone to deficiency, such as pregnant women and older adults. While not all studies show dramatic benefit, a subset indicates that magnesium supplementation can reduce the frequency and severity of leg cramps in individuals with low magnesium levels. The specific form, magnesium citrate malate, is chosen for its high bioavailability, meaning it is well absorbed and tolerated by the body. However, evidence for efficacy in the general population (not deficient in magnesium) is mixed, and large, high-quality randomized controlled trials are limited. Still, clinical guidelines sometimes recommend magnesium supplementation as a reasonable, low-risk intervention for persistent leg cramps when other causes are excluded. In summary, the use of magnesium citrate malate for leg cramps is justified by a moderate body of scientific evidence, particularly in those who may be deficient, but is not universally effective in all cases.

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