Squaw Vine (Mitchella repens) has a long history of use in traditional herbal medicine, particularly among Native American and early European settlers in North America. It has been employed primarily as a remedy to support women’s reproductive health, including the relief of menstrual cramps and as a uterine tonic, especially in the weeks leading up to childbirth. The herb is often found in historical herbal compendia and folk medicine references as a treatment for menstrual discomfort, cramping, and to help regulate menstruation. However, these uses are based on anecdotal reports and traditional practices rather than rigorous scientific studies.

To date, there is a lack of modern clinical trials or robust phytochemical research clearly supporting the efficacy or mechanism of action of Squaw Vine for menstrual cramps. The rating of 1 reflects the presence of traditional use, but negligible scientific validation. Most contemporary herbal texts cite historical use, but also acknowledge the absence of evidence from controlled studies. Therefore, Squaw Vine’s use for menstrual cramps remains rooted in tradition rather than scientific validation.