Evidence supporting the use of: Human growth hormone
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Human growth hormone (HGH) has been explored as a treatment for Crohn’s disease, primarily based on its role in promoting tissue repair and modulating immune responses. The scientific interest began after small studies in the late 1990s and early 2000s suggested that HGH might help reduce intestinal inflammation and promote mucosal healing in patients with Crohn’s disease. The most notable study, published in 2000 in the New England Journal of Medicine, was a randomized, placebo-controlled trial in which HGH (somatropin) was administered to adults with moderate-to-severe Crohn's disease. The results showed a statistically significant improvement in disease activity scores in the HGH group compared to placebo, suggesting some benefit.

However, these findings have not been consistently replicated in larger or longer-term studies, and the use of HGH for Crohn’s disease remains off-label. The evidence base is limited, with most subsequent studies being small, and concerns remain regarding side effects such as edema, arthralgia, insulin resistance, and potential risk of malignancy. Current guidelines do not recommend HGH as a standard therapy for Crohn’s disease, and its use is restricted to research settings or select refractory cases. In summary, while there is early scientific evidence supporting a possible role for HGH in Crohn’s disease, it is weak, insufficient for routine use, and not supported by large-scale clinical validation.

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