Evidence supporting the use of: Lactobacillus mixed)
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus (mixed strains) has been investigated for its potential role in supporting or treating Crohn's Disease (CD), but the overall scientific evidence is limited and mixed. Probiotics, including various Lactobacillus species, are thought to modulate gut microbiota and immune responses, which are disrupted in CD. Some small-scale clinical trials and pilot studies have explored the use of Lactobacillus (alone or in combination with other probiotics) for maintaining remission or reducing symptoms in CD patients. However, the majority of these studies have not demonstrated consistent or significant benefits. For example, a 2008 Cochrane review concluded that there is insufficient evidence to support the use of probiotics, including Lactobacillus, for the maintenance of remission in Crohn’s Disease. Subsequent randomized controlled trials have similarly failed to show robust efficacy, with most reporting no significant difference compared to placebo. In clinical guidelines, such as those from the European Crohn’s and Colitis Organisation (ECCO) and the American Gastroenterological Association, probiotics are not recommended as a standard therapy for Crohn's Disease outside of research settings. In summary, while there is a scientific rationale for exploring probiotics in CD, current clinical evidence does not strongly support the use of mixed Lactobacillus strains for the treatment or maintenance of Crohn’s Disease, resulting in a low evidence rating.

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