Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoferrin is a multifunctional glycoprotein naturally found in milk and other body fluids, known for its antimicrobial, anti-inflammatory, and immunomodulatory properties. The rationale for its use in Crohn’s Disease (CD) stems from these properties, as CD is characterized by chronic intestinal inflammation and dysregulated immune responses. Some preclinical studies and small human trials have suggested that lactoferrin may help modulate the gut microbiota, reduce mucosal inflammation, and improve intestinal barrier function—all relevant to the pathogenesis of CD.

A few clinical studies have explored oral lactoferrin supplementation in patients with inflammatory bowel disease (IBD), including Crohn’s Disease, with some showing improvement in inflammatory markers (like C-reactive protein and fecal calprotectin) and clinical symptoms. However, these studies are generally small, sometimes open-label, and not always specific to CD (often including ulcerative colitis patients as well). The overall body of evidence is therefore limited and of low-to-moderate quality.

There is no long-standing traditional use of lactoferrin for Crohn’s Disease, as its application is based on recent advances in understanding inflammation and immunity. Thus, while there is some scientific rationale and preliminary clinical support, robust, large-scale randomized controlled trials are lacking. Current evidence rates a 2 out of 5 for supporting its use in Crohn’s Disease, indicating promise but insufficient validation for routine clinical use.

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Other ingredients used for Crohn's Disease

Other health conditions supported by lactoferrin

Products containing lactoferrin

Metagenics Probioplex® Intensive Care Powder