Evidence supporting the use of: Omega-3
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Omega-3 fatty acids, particularly EPA and DHA found in fish oil, have been studied for their potential to reduce inflammation in chronic diseases, including Crohn's Disease (CD). The rationale for their use is based on their anti-inflammatory properties, as they can modulate the production of inflammatory cytokines and eicosanoids. Several early studies and small clinical trials suggested that omega-3 supplementation might help maintain remission in Crohn's Disease patients. However, larger, more rigorous randomized controlled trials (RCTs), such as the EPIC-1 and EPIC-2 trials, failed to demonstrate a significant benefit of omega-3 fatty acids in preventing relapse in patients with Crohn's Disease.

Systematic reviews and meta-analyses, including several Cochrane reviews, have concluded that there is insufficient evidence to recommend omega-3 fatty acids as effective therapy for maintaining remission or inducing remission in Crohn's Disease. Despite initial promise and a solid theoretical basis, current clinical evidence does not robustly support the use of omega-3 for Crohn's Disease management. Thus, while the use is scientifically motivated and has been evaluated in clinical research, the quality and consistency of the evidence is low, and omega-3 is not recommended as a standard treatment for Crohn's Disease at this time.

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