Evidence supporting the use of: Peptides (unspecified)
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Peptides, particularly in the context of "peptide-based enteral nutrition" (also called "semi-elemental diets"), have a scientifically supported role in the management of Crohn's Disease, especially in pediatric populations. These diets use formulas in which proteins are broken down into peptides, making them easier to digest and absorb. Several clinical studies, particularly in children, have demonstrated that exclusive enteral nutrition (EEN) using peptide-based or elemental formulas can induce remission in active Crohn's Disease. The efficacy appears comparable to corticosteroids for inducing remission, with the added benefit of promoting mucosal healing and growth in children. The mechanism is thought to involve reduction in antigenic stimulation from whole proteins, modulation of the gut microbiota, and anti-inflammatory effects. However, in adults, the evidence is less robust. Systematic reviews and meta-analyses suggest that while peptide-based diets can be beneficial—especially in patients with malabsorption or intolerance to whole-protein formulas—they are not superior to standard polymeric formulas for inducing remission. Their use is primarily reserved for patients who cannot tolerate or absorb whole proteins due to disease severity or complications. Overall, the use of peptide-based nutrition in Crohn's Disease is guided by clinical evidence, but is not universally superior to other forms of nutritional support except in certain cases.

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