Evidence supporting the use of: Prebiotic blend (proprietary)
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Prebiotic blends, which typically include fibers such as inulin, fructooligosaccharides (FOS), and galactooligosaccharides (GOS), are used to support digestive health by promoting the growth of beneficial gut bacteria. In the context of Crohn’s Disease, there is a growing body of scientific evidence suggesting that alterations in the gut microbiome (dysbiosis) play a role in disease pathogenesis and activity. Prebiotics are hypothesized to help restore a more favorable microbial balance, potentially reducing inflammation and supporting intestinal health. However, the evidence specifically supporting the use of prebiotic blends in Crohn’s Disease is mixed and currently limited. Some small clinical trials have shown that certain prebiotics, like inulin-type fructans, can increase beneficial bacteria (such as bifidobacteria) and may reduce markers of inflammation. Yet, other studies have failed to demonstrate significant clinical benefits in terms of symptom relief or maintenance of remission, and some patients may even experience worsening of gastrointestinal symptoms due to increased gas production. Major clinical guidelines do not currently recommend prebiotics as a standard therapy for Crohn’s Disease, citing insufficient evidence. While there is a plausible rationale and some preliminary data, more robust, large-scale randomized controlled trials are needed. In summary, the use of prebiotic blends for Crohn’s Disease is supported by some scientific rationale and early evidence, but the current overall strength of evidence is low (rated 2/5).

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