Evidence supporting the use of: Psyllium
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Psyllium, a soluble fiber derived from the husks of Plantago ovata seeds, is sometimes used as an adjunct therapy in individuals with Crohn’s Disease (CD). Its use is supported by a modest amount of scientific evidence, mainly from small clinical studies and extrapolations from its effects in other gastrointestinal conditions. Psyllium acts primarily by absorbing water in the gut, forming a gel-like substance that can help regulate bowel movements, which may be beneficial for some CD patients experiencing diarrhea or irregularity. Some studies suggest that soluble fiber such as psyllium may promote the growth of beneficial gut bacteria and increase the production of short-chain fatty acids like butyrate, which can have anti-inflammatory effects on the intestinal mucosa.

However, the evidence for psyllium’s efficacy specifically in Crohn’s Disease is limited and not robust. A handful of small trials and case reports have indicated improvements in bowel regularity and some symptomatic relief, but there is no high-quality, large-scale randomized controlled trial confirming that psyllium alters the course of the disease or induces or maintains remission in Crohn’s patients. In some cases, especially during disease flares or in patients with strictures, fiber supplementation can exacerbate symptoms or cause complications.

In summary, while there is some scientific rationale and limited clinical evidence for the supportive use of psyllium in Crohn’s Disease—mainly for symptom management—its use is not broadly validated as a disease-modifying therapy. Patients should consult healthcare professionals before initiating psyllium supplementation, especially during active disease or in the presence of strictures.

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