Psyllium, a soluble fiber derived from the husks of Plantago ovata seeds, has been investigated for its role in supporting patients with Crohn's Disease, primarily due to its effects on bowel regularity and gut microbiota. There is some scientific rationale for its use: psyllium can help normalize stool consistency and potentially alleviate mild constipation or diarrhea, which are common symptoms in Crohn's Disease. Some studies suggest that soluble fiber like psyllium may have prebiotic effects, fostering beneficial gut bacteria and producing short-chain fatty acids that may support gut mucosal health.

However, the evidence specific to Crohn's Disease is limited. Most clinical trials involving psyllium focus on irritable bowel syndrome or general constipation, with relatively few high-quality studies targeting Crohn's Disease specifically. A small number of trials have shown that psyllium can be safe and may improve stool frequency and form in Crohn's patients in remission, but there is little evidence supporting its use during active disease, and it may even exacerbate symptoms in cases of strictures or significant inflammation.

In summary, while there is a scientific basis for why psyllium might be helpful in Crohn's Disease, especially for symptom management in remission, the evidence is not robust, and its use should be individualized and discussed with a healthcare provider.