Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes, berries, and peanuts, has attracted scientific interest for its potential anti-inflammatory and antioxidant properties. In the context of Crohn's Disease (CD), a chronic inflammatory bowel disorder, some preclinical and limited clinical studies have explored its effects. Laboratory and animal studies suggest that resveratrol may reduce intestinal inflammation by inhibiting pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) and modulating key signaling pathways like NF-κB, which are implicated in the pathogenesis of CD. For example, mouse models of colitis have shown decreased inflammation and tissue damage with resveratrol administration. A small number of human studies have been conducted. One randomized, placebo-controlled pilot study (2019) in adults with mild to moderate CD found that resveratrol supplementation (500 mg/day for 6 weeks) improved some biomarkers of inflammation and quality of life compared to placebo, though clinical remission rates were not significantly different. The evidence is still preliminary, with most data coming from animal models or short-term, small-scale human trials. There is not yet enough robust clinical evidence to recommend resveratrol as a standard therapy for Crohn’s Disease, but mechanistic and early human data provide a scientific rationale for further research.

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