Evidence supporting the use of: Vitamin D
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D is increasingly recognized for its potential role in supporting patients with Crohn's Disease, an inflammatory bowel disease (IBD). Scientific evidence suggests that vitamin D deficiency is more common in people with Crohn's Disease than in the general population, likely due to malabsorption, reduced dietary intake, and decreased sun exposure. Several observational studies have shown that lower serum vitamin D levels are associated with increased disease activity, higher risk of relapse, and poorer quality of life in Crohn's patients. Some clinical trials have explored the effects of vitamin D supplementation, with a few reporting that supplementation may help reduce disease activity and improve clinical outcomes, though results are not entirely consistent across studies.

Mechanistically, vitamin D is known to modulate the immune system and help maintain the integrity of the intestinal barrier—both key factors in Crohn's pathogenesis. It may downregulate pro-inflammatory cytokines and enhance anti-inflammatory responses. Current guidelines often recommend monitoring vitamin D levels in Crohn's patients and correcting deficiencies as part of comprehensive care, though vitamin D is not considered a primary therapy for the disease itself. More high-quality, large-scale randomized controlled trials are needed to establish definitive efficacy for preventing flares or inducing remission. Overall, the use of vitamin D in Crohn's Disease is supported by moderate scientific evidence, primarily for addressing deficiency and possibly for adjunctive benefits in disease management.

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Other health conditions supported by vitamin D

Acne
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Estrogen (low)
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