Evidence supporting the use of: Glucose polymers
For the health condition: Dehydration

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Glucose polymers are scientifically validated for use in the management and treatment of dehydration, particularly as a component of oral rehydration solutions (ORS). The inclusion of glucose (and its polymers, such as maltodextrin) in ORS is based on extensive research demonstrating that glucose facilitates the absorption of sodium and water in the small intestine via the sodium-glucose co-transport mechanism. This principle underpins the effectiveness of ORS, which is recommended by the World Health Organization (WHO) and UNICEF for the treatment of dehydration caused by diarrheal diseases.

Glucose polymers provide a source of carbohydrate that is broken down into glucose, which not only aids in rehydration but also supplies energy. Compared to simple glucose, glucose polymers may reduce the osmolality of the solution, potentially minimizing the risk of osmotic diarrhea while maintaining efficacy in promoting water and electrolyte absorption. Multiple clinical trials and meta-analyses have confirmed that ORS containing glucose or glucose polymers significantly reduces morbidity and mortality associated with dehydration, especially in children.

Thus, the use of glucose polymers in dehydration is strongly supported by scientific evidence, reflected in global health guidelines and clinical practice.

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