Evidence supporting the use of: L-alanyl-l-glutamine
For the health condition: Dehydration

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

L-alanyl-L-glutamine is a dipeptide composed of the amino acids L-alanine and L-glutamine. It is scientifically validated for use in supporting hydration, particularly in clinical settings involving rehydration therapy. The primary advantage of L-alanyl-L-glutamine over free glutamine is its superior stability in aqueous solutions and its enhanced absorption from the gastrointestinal tract. When administered orally or intravenously, L-alanyl-L-glutamine is rapidly hydrolyzed to release L-glutamine and L-alanine, both of which play important roles in cellular metabolism and intestinal health.

In the context of dehydration, L-alanyl-L-glutamine has been shown to improve water and electrolyte absorption in the intestines. Several clinical studies have demonstrated that adding L-alanyl-L-glutamine to oral rehydration solutions (ORS) improves fluid and electrolyte uptake compared to standard ORS, especially in patients with diarrhea-related dehydration. The dipeptide supports the maintenance of gut barrier function and helps reduce the duration and severity of dehydration by promoting sodium and water absorption.

The most robust evidence comes from trials in both adults and children with acute diarrhea, where L-alanyl-L-glutamine–enriched ORS resulted in improved rehydration markers and reduced stool output. Its use is also supported in critical care settings for patients requiring parenteral nutrition to maintain hydration and gut integrity. Thus, the use of L-alanyl-L-glutamine for dehydration is grounded in scientific research, and the quality of evidence supporting its effectiveness is relatively high.

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