Evidence supporting the use of: Potassium aspartate-citrate
For the health condition: Dehydration
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Potassium aspartate-citrate is a combination of potassium salts of aspartic acid and citric acid. Its use in supporting or treating dehydration is scientifically based, primarily due to its role as a source of potassium, an essential electrolyte lost during dehydration. Rehydration solutions, such as oral rehydration salts (ORS), typically contain potassium (often as potassium chloride), sodium, glucose, and sometimes citrate, because these components help restore fluid and electrolyte balance in cases of dehydration due to diarrhea, vomiting, or other causes.
While potassium aspartate-citrate is not as commonly used as potassium chloride in standard ORS formulations recommended by the World Health Organization (WHO), the rationale for its use is similar: to replenish potassium and help correct metabolic acidosis (citric acid and aspartic acid are metabolizable anions that can help buffer acid-base disturbances). Some studies have explored the bioavailability and tolerability of potassium aspartate and potassium citrate, showing that they are effective at increasing serum potassium and are generally well-tolerated.
However, direct clinical trials specifically evaluating potassium aspartate-citrate for dehydration compared to standard potassium salts are limited, and most guidelines still recommend potassium chloride or potassium citrate. Therefore, while the scientific rationale exists and there is some supporting evidence, the evidence base is not as robust as for traditional ORS ingredients, which justifies a moderate evidence rating of 3 out of 5.
More about Potassium aspartate-citrate
More about Dehydration
Other health conditions supported by Potassium aspartate-citrate
ArrhythmiaAthletic and Exercise Aids
Dehydration
Fatigue
Hypertension
Kidney Stones