Evidence supporting the use of: Sulfate (unspecified)
For the health condition: Dehydration
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Sulfate (unspecified) is often present in oral rehydration solutions (ORS) and intravenous fluids used to treat dehydration, though it is not the primary active ingredient. The main scientific rationale for including sulfate in these solutions is related to its role as an essential electrolyte. Sulfate ions help maintain osmotic balance and acid-base status in the body. Most clinical guidelines and World Health Organization (WHO) formulations for ORS focus on sodium, potassium, chloride, glucose, and bicarbonate or citrate, but some formulations may include magnesium sulfate or sodium sulfate as a source of sulfate.
Scientific evidence supports the use of balanced electrolyte solutions for rehydration, particularly in cases of diarrhea-induced dehydration. While sulfate itself is not the critical component (compared to sodium and glucose), its presence in trace amounts contributes to the overall efficacy and safety of rehydration therapy by helping to restore electrolyte balance. Studies have shown that properly formulated electrolyte solutions improve fluid absorption and decrease morbidity and mortality associated with dehydration. However, sulfate is rarely singled out in clinical trials; rather, it is included as part of a mix of electrolytes. Therefore, while sulfate is scientifically validated as a component of rehydration strategies, its specific contribution is less well-studied than those of other electrolytes.
Other health conditions supported by Sulfate (unspecified)
ArthritisConstipation (adults)
Dehydration
Inflammation