Evidence supporting the use of: Anserine
For the health condition: Dementia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Anserine is a naturally occurring dipeptide found in skeletal muscle and brain tissues, especially in birds and fish. Recent scientific investigations have explored its potential in supporting cognitive function and possibly mitigating symptoms of dementia, including Alzheimer's disease. The rationale is primarily based on its antioxidant properties and its ability to inhibit the formation of advanced glycation end-products (AGEs), which are implicated in neurodegeneration.

Several small randomized controlled trials and animal studies have been conducted, particularly focusing on a combination of anserine and carnosine supplementation. For example, a 2018 double-blind, placebo-controlled trial in elderly adults reported that daily supplementation with anserine and carnosine for 12 weeks led to modest improvements in cognitive performance compared to placebo. The proposed mechanisms include reduction of inflammation, oxidative stress, and improved cerebral blood flow.

However, the evidence is still preliminary, with limited sample sizes and short durations. Most clinical studies use combined anserine/carnosine supplements, making it difficult to isolate the effect of anserine alone. To date, there is not enough high-quality, large-scale evidence to definitively support its use in dementia treatment, but early results suggest a potential benefit worth further investigation.

In summary, the use of anserine for dementia is supported by early-stage scientific research but lacks strong, conclusive evidence. It is not part of traditional medical practice for this indication, and more robust clinical trials are needed to confirm its efficacy and safety.

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Products containing anserine

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