Evidence supporting the use of: Chinese salvia root
For the health condition: Dementia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Chinese salvia root, also known as Danshen (Salvia miltiorrhiza), has a long history of use in traditional Chinese medicine, primarily for cardiovascular and cerebrovascular disorders. In recent years, scientific studies have explored its potential neuroprotective effects, including possible benefits in dementia and Alzheimer's disease. The active compounds of Danshen, such as tanshinones and salvianolic acids, exhibit antioxidant, anti-inflammatory, and anti-amyloid properties in various preclinical (cell and animal) studies. These properties are hypothesized to protect neurons from damage associated with dementia.

Some small-scale clinical trials and meta-analyses suggest Danshen may improve cognitive function or slow cognitive decline, particularly when used in combination with other herbs, but these studies are often limited by small sample sizes, short durations, and methodological weaknesses. No large, high-quality randomized controlled trials exist to robustly support its routine use for dementia. Major guidelines do not currently recommend Danshen for dementia treatment. The overall scientific evidence remains preliminary, and while the biological rationale is plausible and animal data are promising, clinical efficacy in humans has not been established. Therefore, the use of Chinese salvia root for dementia is supported by emerging but low-quality scientific evidence, warranting further research.

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