Evidence supporting the use of: Flavanols
For the health condition: Dementia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanols, a subclass of flavonoids found in foods such as cocoa, tea, apples, and berries, have been investigated for their potential neuroprotective effects, including their role in supporting cognitive function and possibly mitigating dementia risk. Some epidemiological studies suggest that higher dietary intake of flavanols is associated with better cognitive performance and a reduced risk of cognitive decline in older adults. Mechanistically, flavanols are thought to exert beneficial effects via antioxidant and anti-inflammatory pathways, improving cerebral blood flow and promoting synaptic plasticity.

However, the clinical evidence remains limited and somewhat inconsistent. A few randomized controlled trials (RCTs) have shown that flavanol-rich interventions, such as high-cocoa chocolate or cocoa supplements, may improve some aspects of cognitive function in older adults or those with mild cognitive impairment. For example, a 2023 RCT published in Alzheimer’s & Dementia found modest improvements in global cognition with daily cocoa flavanol supplementation. Nevertheless, these effects were small, and many studies are limited by short duration, small sample sizes, or methodological weaknesses.

In summary, there is emerging scientific interest and modest evidence supporting the potential cognitive benefits of flavanols, but the current data are insufficient to recommend them as a primary treatment or prevention strategy for dementia. More large-scale, long-term studies are needed to establish efficacy and clarify mechanisms.

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Products containing flavanols

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